2025 NFL Odds Week 3: Lines, Spreads for all 16 Games

Week 2 will be in the running for best early-afternoon slate of the year.

Now, Week 3 kicks off Thursday night, as the Buffalo Bills host the Miami Dolphins.

Here are the lines for every Week 3 matchup at DraftKings Sportsbook as of Sept. 17.

This page may contain affiliate links to legal sports betting partners. If you sign up or place a wager, FOX Sports may be compensated. Read more about Sports Betting on FOX Sports.

(All times ET)

2025 NFL Week 3 Odds

THURSDAY, SEPT. 18

DOLPHINS @ BILLS (8:15 p.m., Prime Video)

Point spread: Bills -12.5 (Bills favored to win by 12.5 points or more, otherwise Dolphins cover)
Moneyline: Bills -750 favorites to win; Dolphins +525 underdogs to win
Total Over/Under: 49.5 points scored by both teams combined

SUNDAY, SEPT. 21

PACKERS @ BROWNS (1:00 p.m., FOX)

Point spread: Packers -8.5 (Packers favored to win by 8.5 points or more, otherwise Browns cover)
Moneyline: Packers -470 favorites to win; Browns +360 underdogs to win
Total Over/Under: 42.5 points scored by both teams combined

COLTS @ TITANS (1:00 p.m., CBS)

Point spread: Colts -4.5 (Colts favored to win by 4.5 points or more, otherwise Titans cover)
Moneyline: Colts -192 favorites to win; Titans +160 underdogs to win
Total Over/Under: 43.5 points scored by both teams combined

BENGALS @ VIKINGS (1:00 p.m., CBS)

Point spread: Vikings -3 (Vikings favored to win by 3 points or more, otherwise Bengals cover)
Moneyline: Vikings -170 favorites to win; Bengals +142 underdogs to win
Total Over/Under: 42.5 points scored by both teams combined

STEELERS @ PATRIOTS (1:00 p.m., CBS)

Point spread: Steelers -1.5 (Steelers favored to win by 1.5 points or more, otherwise Patriots cover)
Moneyline: Steelers -122 favorites to win; Patriots +102 underdogs to win
Total Over/Under: 44.5 points scored by both teams combined

RAMS @ EAGLES (1:00 p.m., FOX)

Point spread: Eagles -3.5 (Eagles favored to win by 3.5 points or more, otherwise Rams cover)
Moneyline: Eagles -185 favorites to win; Rams +154 underdogs to win
Total Over/Under: 44.5 points scored by both teams combined

JETS @ BUCCANEERS (1:00 p.m., FOX)

Point spread: Buccaneers -7 (Buccaneers favored to win by 7 points or more, otherwise Jets cover)
Moneyline: Buccaneers -310 favorites to win; Jets +250 underdogs to win
Total Over/Under: 44.5 points scored by both teams combined

RAIDERS @ COMMANDERS (1:00 p.m., FOX)

Point spread: Commanders -3.5 (Commanders favored to win by 3.5 points or more, otherwise Raiders cover)
Moneyline: Commanders -192 favorites to win; Raiders +160 underdogs to win
Total Over/Under: 44.5 points scored by both teams combined

FALCONS @ PANTHERS (1:00 p.m., FOX)

Point spread: Falcons -5.5 (Falcons favored to win by 5.5 points or more, otherwise Panthers cover)
Moneyline: Falcons -230 favorites to win; Panthers +190 underdogs to win
Total Over/Under: 43.5 points scored by both teams combined

TEXANS @ JAGUARS (1:00 p.m., CBS)

Point spread: Jaguars -1.5 (Jaguars favored to win by 1.5 points or more, otherwise Texans cover)
Moneyline: Jaguars -122 favorites to win; Texans +102 favorites to win
Total Over/Under: 44.5 points scored by both teams combined

BRONCOS @ CHARGERS (4:05 p.m., CBS)

Point spread: Chargers -2.5 (Chargers favored to win by 2.5 points or more, otherwise Broncos cover)
Moneyline: Chargers -148 favorites to win; Broncos +124 underdogs to win
Total Over/Under: 45.5 points scored by both teams combined

SAINTS @ SEAHAWKS (4:05 p.m., CBS)

Point spread: Seahawks -7.5 (Seahawks favored to win by 7.5 points or more, otherwise Saints cover)
Moneyline: Seahawks -395 favorites to win; Saints +310 underdogs to win
Total Over/Under: 41.5 points scored by both teams combined

COWBOYS @ BEARS (4:25 p.m., FOX)

Point spread: Bears -1.5 (Bears favored to win by 1.5 points or more, otherwise Cowboys cover)
Moneyline: Bears -105 favorites to win; Cowboys -115 underdogs to win
Total Over/Under: 50.5 points scored by both teams combined

CARDINALS @ 49ERS (4:25 p.m., FOX)

Point spread: 49ers -1.5 (49ers favored to win by 1.5 points or more, otherwise Cardinals cover)
Moneyline: 49ers -135 favorites to win; Cardinals +114 underdogs to win
Total Over/Under: 44.5 points scored by both teams combined

CHIEFS @ GIANTS (8:20 p.m., NBC)

Point spread: Chiefs -6 (Chiefs favored to win by 6 points or more, otherwise Giants cover)
Moneyline: Chiefs -325 favorites to win; Giants +260 underdogs to win
Total Over/Under: 45.5 points scored by both teams combined

MONDAY, SEPT. 22

LIONS @ RAVENS (8:15 p.m., ABC/ESPN)

Point spread: Ravens -4.5 (Ravens favored to win by 4.5 points or more, otherwise Lions cover)
Moneyline: Ravens -225 favorites to win; Lions +185 underdogs to win
Total Over/Under: 52.5 points scored by both teams combined

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, and follow leagues, teams and players to receive a personalized newsletter daily!

What did you consider this story?